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Article

No mutations in TPIT, a corticotroph-specific gene, in human tumoral pituitary ACTH-secreting cells.

Journal of endocrinological investigation - 1 Dec 2005

Bucciarelli L G, Pecori Giraldi F, Cavagnini F

Abstract excerpt

BACKGROUND: TPIT is a recently identified transcription factor specific to proopiomelanocortin (POMC)-expressing cells within the pituitary and plays a pivotal role in the embryonal development of POMC lineage. As with other transcription factors, TPIT could theoretically also be involved in corticotroph adenomatous transformation and ACTH hypersecretion and published data indicate that TPIT is present in normal...

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Source

Identifiers

PMID: 16483181
DOI: 10.1007/BF03345341

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

No mutations in TPIT, a corticotroph-specific gene, in human tumoral pituitary ACTH-secreting cells.PMID 16483181Read ↗

Differential Regulation of Proopiomelanocortin and Pituitary-Restricted Transcription Factor (TPIT), a New Marker of Normal and Adenomatous Human CorticotrophsSemantic proximity Read ↗

Heterogeneity of TPIT expression in ACTH-secreting extra-pituitary neuroendocrine tumors (NETs) supports the existence of different cellular programs in pancreatic and pulmonary NETsSemantic proximity Read ↗

Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency.Semantic proximity Read ↗

A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins.Semantic proximity Read ↗

TPIT mutations are associated with early-onset, but not late-onset isolated ACTH deficiencySemantic proximity Read ↗

Phenotypic homogeneity and genotypic variability in a large series of congenital isolated ACTH-deficiency patients with TPIT gene mutations.Semantic proximity Read ↗

Two Distinctive POMC Promoters Modify Gene Expression in Cushing DiseaseSemantic proximity Read ↗

Pit-1 gene expression in the human pituitary and pituitary adenomas.Semantic proximity Read ↗

Tpit determines alternate fates during pituitary cell differentiation.Semantic proximity Read ↗

Decreased expression of corticotropin-releasing factor-binding protein mRNA in ACTH-secreting pituitary adenomas.Semantic proximity Read ↗

Expression of glucocorticoid receptor gene isoforms in corticotropin-secreting tumors.Semantic proximity Read ↗

Expression of pituitary tumor transforming gene (PTTG) in human pituitary macroadenomasSemantic proximity Read ↗

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