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Article

Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency.

Genes & development - 15 Mar 2003

Pulichino Anne-Marie, Vallette-Kasic Sophie, Couture Catherine, Gauthier Yves, Brue Thierry, David Michel, Malpuech Georges, Deal Cheri, Van Vliet Guy, De Vroede Monique, Riepe Felix G, Partsch Carl-Joachim, Sippell Wolfgang G, Berberoglu Merih, Atasay Begüm, Drouin Jacques

Abstract excerpt

Tpit is a highly cell-restricted transcription factor that is required for expression of the pro-opiomelanocortin (POMC) gene and for terminal differentiation of the pituitary corticotroph lineage. Its exclusive expression in pituitary POMC-expressing cells has suggested that its mutation may cause isolated deficiency of pituitary adrenocorticotropin (ACTH). We now show that Tpit-deficient mice constitute a model...

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Source

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Identifiers

PMID: 12651888
DOI: 10.1101/gad.1065603
PMCID: PMC196015

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency.PMID 12651888Read ↗

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