Article
The gene ncgl2918 encodes a novel maleylpyruvate isomerase that needs mycothiol as cofactor and links mycothiol biosynthesis and gentisate assimilation in Corynebacterium glutamicum.
The Journal of biological chemistry - 21 Apr 2006
Feng Jie, Che Yongsheng, Milse Johanna, Yin Ya-Jie, Liu Lei, Rückert Christian, Shen Xi-Hui, Qi Su-Wei, Kalinowski Jörn, Liu Shuang-Jiang
Abstract excerpt
Data mining of the Corynebacterium glutamicum genome identified 4 genes analogous to the mshA, mshB, mshC, and mshD genes that are involved in biosynthesis of mycothiol in Mycobacterium tuberculosis and Mycobacterium smegmatis. Individual deletion of these genes was carried out in this study. Mutants mshC- and mshD- lost the ability to produce mycothiol, but mutant mshB- produced mycothiol as the wild type did....
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