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Article

Ripe areca nut extract induces G1 phase arrests and senescence-associated phenotypes in normal human oral keratinocyte.

Carcinogenesis - 1 Jun 2006

Lu Ssu-Yi, Chang Kuo-Wei, Liu Chung-Ji, Tseng Yu-Hsin, Lu Hsuan-Hsuan, Lee Suz-Ying, Lin Shu-Chun

Abstract excerpt

Around 200-600 million Asians chew areca (also called betel), which contains a mixture of areca nut and other ingredients. Epidemiological evidences indicated that areca use is tightly linked to oral carcinogenesis. This study investigated the effects of ripe areca nut extract (ANE) on cultured normal human oral keratinocyte (NHOK). Acute subtoxic ANE treatment inhibited DNA synthesis and induced cell cycle...

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PMID: 16474177
DOI: 10.1093/carcin/bgi357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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