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Article

Genetic damage in cultured human keratinocytes stressed by long-term exposure to areca nut extracts.

Mutation research - 25 Jul 2006

Lai Kuo-Chu, Lee Te-Chang

Abstract excerpt

Chewing betel quid (BQ) is a popular habit worldwide. A causal association between BQ chewing and oral cancer has been well documented. Emerging evidence indicates that sustained exposure to stress induces epigenetic reprogramming of some mammalian cells and increases the mutation rate to accelerate adaptation to stressful environments. In this study, we first confirmed that 24-h treatment with areca nut extracts...

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Identifiers

PMID: 16488451
DOI: 10.1016/j.mrfmmm.2006.01.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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