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Article

Translational regulators maintain totipotency in the Caenorhabditis elegans germline.

Science (New York, N.Y.) - 10 Feb 2006

Ciosk Rafal, DePalma Michael, Priess James R

Abstract excerpt

The molecular mechanisms that maintain totipotency of the germline are not well understood. Here, we show that two conserved translational regulators, MEX-3 and GLD-1, are essential for maintaining totipotency in the Caenorhabditis elegans germline. In mex-3 gld-1 mutants, germ cells transdifferentiate into various somatic cell types such as muscles or neurons. Our findings implicate RNA regulation in the...

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Identifiers

PMID: 16469927
DOI: 10.1126/science.1122491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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