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Article

Signs of positive selection of somatic mutations in human cancers detected by EST sequence analysis.

BMC cancer - 9 Feb 2006

Babenko Vladimir N, Basu Malay K, Kondrashov Fyodor A, Rogozin Igor B, Koonin Eugene V

Abstract excerpt

BACKGROUND: Carcinogenesis typically involves multiple somatic mutations in caretaker (DNA repair) and gatekeeper (tumor suppressors and oncogenes) genes. Analysis of mutation spectra of the tumor suppressor that is most commonly mutated in human cancers, p53, unexpectedly suggested that somatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16469093
DOI: 10.1186/1471-2407-6-36
PMCID: PMC1431556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16469093-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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