A slipped‐mispairing mutation in AgrA of laboratory strains and clinical isolates results in delayed activation of agr and failure to translate δ‐ and α‐haemolysins

Abstract excerpt

agr is a global regulator of staphylococcal virulence and other accessory gene functions, especially including the haemolysins. Lack of haemolysin production therefore generally represents a defect in agr function. An example of this is Staphylococcus aureus strain RN4220, a widely used laboratory strain that carries a nitrosoguanidine (MNNG)-induced mutation enabling it to accept DNA from Escherichia coli and...

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