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Article

FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jul 2006

Dridi Sami, Ververken Cedric, Hillgartner F Bradley, Arckens Lutgarde, Lutgarde Arckens, Van der Gucht Estel, Cnops Lieselotte, Decuypere Eddy, Buyse Johan

Abstract excerpt

Cerulenin, a natural fatty acid synthase (FAS) inhibitor, and its synthetic analog C75 are hypothesized to alter the metabolism of neurons in the hypothalamus that regulate ingestive behavior to cause a profound decrease of food intake and an increase in metabolic rate, leading to body weight loss. The bulk of data exclusively originates from mammals (rodents); however, such effects are currently lacking in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Feeding Behavior

Share to Gene Expression Regulation, Enzymologic

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Share to Receptors, Melanocortin

Source

Identifiers

PMID: 16455759
DOI: 10.1152/ajpregu.00899.2005

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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