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Article

Regulator of G-protein signaling 2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cells.

Oncogene - 22 Jun 2006

Cao X, Qin J, Xie Y, Khan O, Dowd F, Scofield M, Lin M-F, Tu Y

Abstract excerpt

Hormones acting through G protein-coupled receptors (GPCRs) can cause androgen-independent activation of androgen receptor (AR) in prostate cancer cells. Regulators of G-protein signaling (RGS) proteins, through their GTPase activating protein (GAP) activities, inhibit GPCR-mediated signaling by inactivating G proteins. Here, we identified RGS2 as a gene specifically downregulated in androgen-independent prostate...

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Share to Mitogen-Activated Protein Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16449965
DOI: 10.1038/sj.onc.1209408

Genes

RGS2

Variants

Provenance

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