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TMPRSS2-ERG activates NO-cGMP signaling in prostate cancer cells

4 Feb 2019

Abstract excerpt

The aberrant activation of the ERG oncogenic pathway due to the TMPRSS2-ERG gene fusion is the major event that contributes to prostate cancer (PCa) development. However, the critical downstream effectors that can be therapeutically targeted remain to be identified. In this study, we have found that the expression of the α1 and β1 subunits of soluble guanylyl cyclase (sGC) was directly and specifically regulated...

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PMID: 30718921
DOI: 10.1038/s41388-019-0730-9

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