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Chromatin Decondensation and Nuclear Reprogramming by Nucleoplasmin

31 Jan 2006

Abstract excerpt

Somatic cell nuclear cloning has repeatedly demonstrated striking reversibility of epigenetic regulation of cell differentiation. Upon injection into eggs, the donor nuclei exhibit global chromatin decondensation, which might contribute to reprogramming the nuclei by derepressing dormant genes. Decondensation of sperm chromatin in eggs is explained by the replacement of sperm-specific histone variants with...

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PMID: 16449640
DOI: 10.1128/mcb.26.4.1259-1271.2006

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