Article
Sarcoidosis HLA class II genotyping distinguishes differences of clinical phenotype across ethnic groups.
Human molecular genetics - 15 Oct 2010
Sato Hiroe, Woodhead Felix A, Ahmad Tariq, Grutters Jan C, Spagnolo Paolo, van den Bosch Jules M M, Maier Lisa A, Newman Lee S, Nagai Sonoko, Izumi Takateru, Wells Athol U, du Bois Roland M, Welsh Kenneth I
Abstract excerpt
The HLA class II (DRB1 and DQB1) associations with sarcoidosis have been studied by several groups but often without consistent results. In this paper, we consider the hypothesis that observed inconsistencies relate to distinct, genetically encoded disease phenotypes which differ in prevalence between centres. We therefore typed HLA-DRB1 and DQB1 in 340 UK, 139 Dutch and 163 Japanese sarcoidosis patients and,...
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