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Article

Effect of mutation on enzyme motion in dihydrofolate reductase.

Journal of the American Chemical Society - 2 Apr 2003

Watney James B, Agarwal Pratul K, Hammes-Schiffer Sharon

Abstract excerpt

Hybrid quantum-classical molecular dynamics simulations of a mutant Escherichia coli dihydrofolate reductase enzyme are presented. Although residue 121 is on the exterior of the enzyme, experimental studies have shown that the mutation of Gly-121 to valine reduces the rate of hydride transfer by...

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Source

Identifiers

PMID: 12656604
DOI: 10.1021/ja028487u

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12656604-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Effect of mutation on enzyme motion in dihydrofolate reductase.PMID 12656604Read ↗

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