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Article

The catalytic effect of dihydrofolate reductase and its mutants is determined by reorganization energies.

Biochemistry - 22 May 2007

Liu Hanbin, Warshel Arieh

Abstract excerpt

The effect of distant mutations on the catalytic reaction of dihydrofolate reductase (DHFR) is reexamined by empirical valence bond simulations. The simulations reproduce for the first time the changes in the observed rate constants (without the use of adjustable parameters for this purpose) and show that the changes in activation barriers are strongly correlated with the corresponding changes in the...

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Source

Identifiers

PMID: 17469852
DOI: 10.1021/bi700201w

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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