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Article

The selective advantage of alpha1-antitrypsin deficiency.

American journal of respiratory and critical care medicine - 15 May 2006

Lomas David A

Abstract excerpt

The S- and Z-deficiency alleles of alpha1-antitrypsin are found in more than 20% of some white populations. This high gene frequency suggests that these mutations confer a selective advantage, but the biologic mechanism of this has remained obscure. It is now well recognized that the S and Z alleles result in a conformational transition within the alpha1-antitrypsin molecule and the formation of polymers that are...

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Identifiers

PMID: 16439713
DOI: 10.1164/rccm.200511-1797PP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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