Effect of a mutation on the structure and dynamics of an alpha-helical antifreeze protein in water and ice.

doi:10.1002/prot.20889

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Article

Effect of a mutation on the structure and dynamics of an alpha-helical antifreeze protein in water and ice.

Proteins - 15 May 2006

Graether Steffen P, Slupsky Carolyn M, Sykes Brian D

Abstract excerpt

One strategy of psychrophilic organisms to survive subzero temperature is to produce antifreeze protein (AFPs), which inhibit the growth of macromolecular ice. To better understand the binding mechanism, the structure and dynamics of several AFPs have been studied by nuclear magnetic resonance (NMR) and X-ray crystallography. The results have shown that different organisms can use diverse structures (alpha-helix,...

Topics

Animals
Antifreeze Proteins
Flounder
Ice
Mutation
Protein Structure, Secondary
Structure-Activity Relationship
Thermodynamics
Water

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Open in PubMed

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PMID: 16437556
DOI: 10.1002/prot.20889

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