Article
GAP-43 heterozygous mice show delayed barrel patterning, differentiation of radial glia, and downregulation of GAP-43.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology - 1 Feb 2006
McIlvain Vera, McCasland James S
Abstract excerpt
GAP-43 heterozygous (HZ) mice exhibit abnormal thalamocortical pathfinding, fasciculation, and terminal arborization at postnatal day 7 (P7). Here we tested whether these defects are correlated with delayed development of HZ cortical patterns. We assessed the rate of barrel segregation and radial glia differentiation in wild-type (WT) and HZ cortices. Since GAP-43 is involved in some forms of neural plasticity,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.