Article
Spontaneous recovery of injured Achilles tendon in inducible nitric oxide synthase gene knockout mice.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Jan 2006
Xia W, Wang Y, Appleyard R C, Smythe G A, Murrell G A C
Abstract excerpt
OBJECTIVE AND DESIGN: To determine if inducible nitric oxide synthase (iNOS) gene could affect Achilles tendon healing using iNOS gene knockout mice. METHODS: 21 iNOS knockout (iNOS(-/-)) mice and 8 of the wild type (iNOS(+/+)) mice were utilized in this study. Group 1: iNOS(+/+) mice (n = 8), group 2: iNOS(-/-) mice (n = 11) and group 3: iNOS(-/-) with a NOS inhibitor, (aminoguanidine, 500 mg/kg/day, via an...
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