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Article

Plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility.

The Journal of biological chemistry - 24 Mar 2006

Ueno Seiji, Saito Seiichi, Wada Tadashi, Yamaguchi Kazunori, Satoh Makoto, Arai Yoichi, Miyagi Taeko

Abstract excerpt

Human plasma membrane-associated sialidase (NEU3), specifically hydrolyzing gangliosides, plays crucial roles in the regulation of cell surface functions. Here we demonstrate that NEU3 mRNA level are increased in renal cell carcinomas (RCCs) compared with adjacent non-tumor tissues, significantly correlating with elevation of interleukin-6 (IL-6), a pleiotropic cytokine that has been implicated in immune...

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Source

Identifiers

PMID: 16428383
DOI: 10.1074/jbc.M509668200

Genes

NEU3
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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