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Article

The Central Role of the Alternative Complement Pathway in Human Disease

1 Feb 2006

Abstract excerpt

The complement system is increasingly recognized as important in the pathogenesis of tissue injury in vivo following immune, ischemic, or infectious insults. Within the complement system, three pathways are capable of initiating the processes that result in C3 activation: classical, alternative, and lectin. Although the roles that proinflammatory peptides and complexes generated during complement activation play...

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PMID: 16424154
DOI: 10.4049/jimmunol.176.3.1305

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