Article
Strategies for characterizing highly polymorphic markers in human gene mapping.
American journal of human genetics - 1 Aug 1992
Ott J
Abstract excerpt
Before new markers are thoroughly characterized, they are usually screened for high polymorphism on the basis of a small panel of individuals. Four commonly used screening strategies are compared in terms of their power to correctly classify a marker as having heterozygosity of 70% or higher. A small number of typed individuals (10, say) are shown to provide good discrimination power between low- and...
Topics
- Alleles
- Chromosome Mapping
- Female
- Gene Frequency
- Genetic Linkage
- Genetic Markers
- Heterozygote
- Humans
- Male
- Pedigree
- Polymorphism, Genetic