Article
Decision forest analysis of large-scale sib-pair identical-by-decent profiles for locating the underlying disease genes for alcoholism in human.
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences - 18 Feb 2006
Li Xia, Rao Shao-qi, Zhang Wei, Guo Zheng, Jiang Wei, Du Lei
Abstract excerpt
OBJECTIVE: To extract the relevant SNPs for alcoholism using sib-pair IBD profiles of pedigrees. METHODS: We used the ensemble decision approach, a supervised learning approach based on decision forests, to locate alcoholism relevant SNPs using genome-wide SNP data. RESULTS: Application to a publicly available large dataset of 100 simulated replicates for three American populations (http://www.gaworkshop.org/)...
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