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Article

Expression of p16INK4A in cervical precancerous lesions that is unlikely to be preventable by human papillomavirus vaccines.

Cancer - 1 Dec 2016

Badiga Suguna, Chambers Michelle M, Huh Warner, Eltoum Isam-Eldin A, Piyathilake Chandrika J

Abstract excerpt

BACKGROUND: Whether higher grade cervical intraepithelial neoplasia (CIN grade 2 or greater [CIN ≥ 2]) that develops because of human papillomavirus (HPV) genotypes not included in vaccines may progress to cervical cancer is largely unknown. The objectives of this study were to document expression of the cyclin-dependent kinase inhibitor 2A (p16) tumor-suppressor protein p16INK4A as a biomarker of cervical...

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Identifiers

PMID: 27479745
DOI: 10.1002/cncr.30229
PMCID: PMC5115942

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