Article
The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration.
Cancer biology & therapy - 1 Mar 2006
McDonald J Matthew, Dunlap Sarah, Cogdell David, Dunmire Valerie, Wei Qingyi, Starzinski-Powitz Anna, Sawaya Raymond, Bruner Janet, Fuller Gregory N, Aldape Kenneth, Zhang Wei
Abstract excerpt
Allelic loss of the short arm of chromosome 1 has been observed frequently in oligodendroglioma (60-80%). We evaluated 177 oligodendroglial tumor samples and defined a consensus region of deletion of approximately 630 kb. This region contains a single gene, SHREW1, which encodes a novel transmembrane protein in adherens junctions. Whereas a mutation was not detected in the coding region of the SHREW1 gene in...
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