Article
Association of interferon-gamma +874A polymorphism with reduced long-term inflammatory response in haemodialysis patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 May 2006
Biolo Gianni, Amoroso Antonio, Savoldi Silvana, Bosutti Alessandra, Martone Massimiliano, Pirulli Doroti, Bianco Francesco, Ulivi Sheila, Bertok Sara, Artero Mary, Barazzoni Rocco, Zanetti Michela, Grassi Gabriele, Guarnieri Gianfranco, Panzetta Giovanni
Abstract excerpt
BACKGROUND: We have studied the effects of interferon (IFN)-gamma allelic variations on expression levels of pro- and anti-inflammatory cytokines and on long-term inflammatory status in haemodialysis patients. METHODS: Genotyping was performed in 123 patients for single nucleotide polymorphisms in the first intron of the IFN-gamma gene (+874 T/A). They were prospectively followed for 2 years. Cytokine mRNA levels...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.