Article
The interleukin-10 promoter genotype determines clinical immune function in hemodialysis patients.
Kidney international - 1 Dec 2001
Girndt M, Sester U, Sester M, Deman E, Ulrich C, Kaul H, Köhler H
Abstract excerpt
BACKGROUND: Immune dysfunction and the impaired hepatitis B vaccination response are complications of chronic renal failure that are tightly associated with inflammation induced by uremia and blood-membrane contacts. Proinflammatory cytokines, such as interleukin (IL)-6, are counter-regulated by IL-10 with a large interindividual variability. Part of the variability of cytokine production is genetically...
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