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Article

Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Oct 2003

Ferrante Robert J, Kubilus James K, Lee Junghee, Ryu Hoon, Beesen Ayshe, Zucker Birgit, Smith Karen, Kowall Neil W, Ratan Rajiv R, Luthi-Carter Ruth, Hersch Steven M

Abstract excerpt

The precise cause of neuronal death in Huntington's disease (HD) is unknown. Although no single specific protein-protein interaction of mutant huntingtin has emerged as the pathologic trigger, transcriptional dysfunction may contribute to the neurodegeneration observed in HD. Pharmacological treatment using the histone deacetylase inhibitor sodium butyrate to modulate transcription significantly extended survival...

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PMID: 14561870
PMCID: PMC6740577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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