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Article

Declining transition/transversion ratios through time reveal limitations to the accuracy of nucleotide substitution models.

BMC evolutionary biology - 11 Mar 2015

Duchêne Sebastián, Ho Simon Y W, Holmes Edward C

Abstract excerpt

BACKGROUND: Genetic analyses of DNA sequences make use of an increasingly complex set of nucleotide substitution models to estimate the divergence between gene sequences. However, there is currently no way to assess the validity of nucleotide substitution models over short time-scales and with limited mutational accumulation. RESULTS: We show that quantifying the decline in the ratio of transitions to...

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Identifiers

PMID: 25886870
DOI: 10.1186/s12862-015-0312-6
PMCID: PMC4358783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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