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Article

Genetic variation of the renin-angiotensin system and chronic kidney disease progression in black individuals in the atherosclerosis risk in communities study.

Journal of the American Society of Nephrology : JASN - 1 Feb 2006

Hsu Charles Chia-Chuen, Bray Molly S, Kao W H Linda, Pankow James S, Boerwinkle Eric, Coresh Josef

Abstract excerpt

The renin-angiotensin system (RAS) regulates BP and may affect chronic kidney disease (CKD) through induction of tissue growth and fibrosis. The angiotensinogen (AGT) promoter G(-6) allele lowers transcription and is inversely associated with hypertension. In white individuals, the A1166C 3'-UTR variant of angiotensin II type 1 receptor (AT1R) has been associated with CKD. CKD associations with these RAS genes...

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Source

Identifiers

PMID: 16396964
DOI: 10.1681/ASN.2005050468

Genes

AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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