Article
Evolution of the DRD2 gene haplotype and its association with alcoholism in Mexican Americans.
Alcohol (Fayetteville, N.Y.) - 1 Jun 2005
Luo Huai-Rong, Hou Zhen-Fang, Wu Julia, Zhang Ya-Ping, Wan Yu-Jui Yvonne
Abstract excerpt
The human D2 dopamine receptor gene (DRD2) plays a central role in the neuromodulation of appetitive behaviors and is implicated in having a possible role in susceptibility to alcoholism. We genotyped an SNP in DRD2 Exon 8 in 251 nonalcoholic, unrelated, healthy controls and 200 alcoholic Mexican Americans. The DRD2 haplotypes were analyzed using the Exon 8 genotype in combination with five other SNP genotypes,...
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