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Article

Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography.

Diabetes - 1 Jan 2006

Otonkoski Timo, Näntö-Salonen Kirsti, Seppänen Marko, Veijola Riitta, Huopio Hanna, Hussain Khalid, Tapanainen Päivi, Eskola Olli, Parkkola Riitta, Ekström Klas, Guiot Yves, Rahier Jacques, Laakso Markku, Rintala Risto, Nuutila Pirjo, Minn Heikki

Abstract excerpt

Congenital hyperinsulinism of infancy (CHI) is characterized by severe hypoglycemia due to dysregulated insulin secretion, associated with either focal or diffuse pathology of the endocrine pancreas. The focal condition is caused by a paternally inherited mutation in one of the genes encoding the subunits of the beta-cell ATP-sensitive potassium channel (SUR1/ABCC8 or Kir6.2/KCNJ11) and somatic loss of maternal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16380471

Genes

ABCC8
KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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