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Article

The heterogeneity of focal forms of congenital hyperinsulinism.

The Journal of clinical endocrinology and metabolism - 1 Jan 2012

Ismail Dunia, Kapoor Ritika R, Smith Virpi V, Ashworth Michael, Blankenstein Oliver, Pierro Agostino, Flanagan Sarah E, Ellard Sian, Hussain Khalid

Abstract excerpt

BACKGROUND: Congenital hyperinsulinism (CHI) is a cause of persistent hypoglycemia due to unregulated insulin secretion from pancreatic β-cells. Histologically, there are two major subgroups, focal and diffuse. Focal CHI is typically unresponsive to diazoxide and can be cured with surgical removal of the focal lesion. AIMS: We report on three patients with focal CHI to illustrate the marked clinical, genetic,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22031516
DOI: 10.1210/jc.2011-1628
PMCID: PMC7611920

Genes

ABCC8

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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