Article
Influence of beta-2 adrenergic receptor gene polymorphism on the hemodynamic response to propranolol in patients with cirrhosis.
Hepatology (Baltimore, Md.) - 1 Jan 2006
Turnes Juan, Hernández-Guerra Manuel, Abraldes Juan G, Bellot Pau, Oliva Rafael, García-Pagán Juan Carlos, Bosch Jaime
Abstract excerpt
The beta-2-adrenergic receptor (beta(2-)-AR) has several single-nucleotide polymorphisms. These influence the functional response to adrenergic stimulation; genotypes homozygous for Gly16-Glu27 or Gly16-Gln27 alleles (Gly16-Glu/Gln27 haplotypes) are associated with enhanced response, whereas genotypes homozygous for Arg16-Gln27 alleles (Arg16-Gln27) show a decreased response. We hypothesized that gene...
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