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Article

Genetic Barriers to Resistance and Impact on Clinical Response

1 Feb 2005

Abstract excerpt

The development of drug resistance and cross-resistance continues to pose a challenge to successful long-term antiretroviral therapy despite the availability of new antiretroviral agents. The genetic barrier to resistance of a regimen does not directly correlate with its effectiveness. For some regimens with a low genetic barrier to resistance, however, the emergence of only 1 or 2 key resistance mutations may...

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PMID: 16369295
DOI: 10.1186/1758-2652-7-3-69

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