Article
Association between human atrial natriuretic peptide Val7Met polymorphism and baseline blood pressure, plasma trough irbesartan concentrations, and the antihypertensive efficacy of irbesartan in rural Chinese patients with essential hypertension.
Clinical therapeutics - 1 Nov 2005
Zhang Shanchun, Mao Guangyun, Zhang Yan, Tang Genfu, Wen Yufeng, Hong Xiumei, Jiang Shanqun, Yu Yunxian, Xu Xiping
Abstract excerpt
BACKGROUND: Individual variations in the pharmacokinetics and pharmacodynamics of antihypertensive drugs are influenced by genetic and environmental factors. The ANP gene, which encodes the precursor of atrial natriuretic peptide (ANP), is among the candidate genes for genetic susceptibility to hypertension. OBJECTIVE: This study examined the relationship between ANP Val7Met polymorphism (Single Nucleotide...
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