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Article

Perturbations in hypoxia detection: a shared link between hereditary and sporadic tumor formation?

Medical hypotheses - 1 Jan 2006

Sharifi Nima, Farrar William L

Abstract excerpt

The discovery and characterization of the von Hippel Lindau (VHL) syndrome has brought about tremendous advances in understanding the molecular mechanisms of renal cell carcinoma. VHL mutations are known to act through hypoxia inducible factor, which has a physiologic role in detecting hypoxia. Recent investigations into other hereditary forms of kidney cancer with mutations in genes involving energy metabolism...

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Source

Identifiers

PMID: 16364563
DOI: 10.1016/j.mehy.2005.11.003

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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