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Article

Effect of vectors on human endothelial cell signal transduction: implications for cardiovascular gene therapy.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2006

Tan Peng H, Xue Shao-An, Manunta Maria, Beutelspacher Sven C, Fazekasova Henrieta, Alam A K M Shamsul, McClure Myra O, George Andrew J T

Abstract excerpt

OBJECTIVE: Endothelium is an important target for gene therapy. We have investigated the effect of viral and nonviral vectors on the phenotype and function of endothelial cells (ECs) and developed methods to block any activation caused by these vectors. METHODS AND RESULTS: Transduction of ECs with viral vectors, including adenovirus, lentiviruses, and Moloney murine leukemia virus, can induce a pro-inflammatory...

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Identifiers

PMID: 16357316
DOI: 10.1161/01.ATV.0000200083.95349.9e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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