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Improved Adenovirus Vectors for Infection of Cardiovascular Tissues

1 Apr 2001

Abstract excerpt

To identify improved adenovirus vectors for cardiovascular gene therapy, a library of adenovirus vectors based on adenovirus serotype 5 (Ad5) but carrying fiber molecules of other human serotypes, was generated. This library was tested for efficiency of infection of human primary vascular endothelial cells (ECs) and smooth muscle cells (SMCs). Based on luciferase, LacZ, or green fluorescent protein (GFP) marker...

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PMID: 11238859
DOI: 10.1128/jvi.75.7.3335-3342.2001

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