Article
Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435C-->T polymorphism at the multidrug resistance gene 1.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Jan 2006
Rodríguez Nóvoa Sonia, Barreiro Pablo, Rendón Ana, Barrios Ana, Corral Angélica, Jiménez-Nacher Inmaculada, González-Lahoz Juan, Soriano Vincent
Abstract excerpt
The 3435C-->T polymorphism at the multidrug resistance gene 1 (MDR1) was examined in 74 patients with human immunodeficiency virus who initiated atazanavir therapy. The MDR1 genotype distribution at position 3435 was 28% CC, 45% CT, and 27% TT. Plasma levels of atazanavir were significantly higher in patients with genotype CC than in those with CT or TT, and bilirubin levels correlated with atazanavir concentrations.
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