Article
Cost-effectiveness analysis of UGT1A1 genetic testing to inform antiretroviral prescribing in HIV disease.
Antiviral therapy - 1 Jan 2013
Schackman Bruce R, Haas David W, Becker Jessica E, Berkowitz Bethany K, Sax Paul E, Daar Eric S, Ribaudo Heather J, Freedberg Kenneth A
Abstract excerpt
BACKGROUND: Homozygosity for UGT1A1*28/*28 has been reported to be associated with atazanavir-associated hyperbilirubinaemia and premature atazanavir discontinuation. We assessed the potential cost-effectiveness of UGT1A1 testing to inform the choice of an initial protease-inhibitor-containing regimen in antiretroviral therapy (ART)-naive individuals. METHODS: We used the Cost-Effectiveness of Preventing AIDS...
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