Article
Concordance, disease progression, and heritability of coeliac disease in Italian twins.
Gut - 1 Jun 2006
Nisticò L, Fagnani C, Coto I, Percopo S, Cotichini R, Limongelli M G, Paparo F, D'Alfonso S, Giordano M, Sferlazzas C, Magazzù G, Momigliano-Richiardi P, Greco L, Stazi M A
Abstract excerpt
BACKGROUND AND AIMS: We adopted the twin method to disentangle the genetic and environmental components of susceptibility to coeliac disease (CD). We estimated disease concordance rate by zygosity and HLA genotypes, discordance times, progression rates to disease, and heritability. METHODS: We crosslinked the Italian Twin Registry with the membership lists of the Italian Coeliac Disease Association and recruited...
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