Article
A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys.
Pharmacogenetics and genomics - 1 Jan 2006
Rodríguez Santiago, Huang Shuwen, Chen Xiao-he, Gaunt Tom R, Syddall Holly E, Gilg Julie A, Miller George J, Cooper Cyrus C, Cook Derek G, Whincup Peter H, Day Ian N M
Abstract excerpt
OBJECTIVES: Recent studies suggest an association between a microsatellite locus (TH01) located in intron 1 of the tyrosine hydroxylase gene (TH) and nicotine dependence. We aimed here to study whether both TH01 and haplotypes of the wider IGF2-INS-TH region influence initiation of regular smoking in current smokers. METHODS: A total of 3637 individuals from three independent studies (two of adults and one of...
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