Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome.

doi:10.1161/CIRCULATIONAHA.105.520999

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Article

Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome.

Circulation - 13 Dec 2005

Frustaci Andrea, Priori Silvia G, Pieroni Maurizio, Chimenti Cristina, Napolitano Carlo, Rivolta Ilaria, Sanna Tommaso, Bellocci Fulvio, Russo Matteo Antonio

Abstract excerpt

BACKGROUND: The role of structural heart disease and sodium channel dysfunction in the induction of electrical instability in Brugada syndrome is still debated. METHODS AND RESULTS: We studied 18 consecutive patients (15 males, 3 females; mean age 42.0+/-12.4 years) with clinical phenotype of Brugada syndrome and normal cardiac structure and function on noninvasive examinations. Clinical presentation was...

Topics

Adult
Aneurysm
Apoptosis
Biopsy
DNA Mutational Analysis
Female
Heart Conduction System
Heterozygote
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle Proteins

Myocarditis

Myocytes, Cardiac

NAV1.5 Voltage-Gated Sodium Channel

Phenotype

Sodium Channels

Syncope

Source

Open in PubMed

Identifiers

PMID: 16344400
DOI: 10.1161/CIRCULATIONAHA.105.520999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16344400-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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