Elevated oxidative stress is associated with ventricular fibrillation episodes in patients with Brugada-type electrocardiogram without SCN5A mutation.

doi:10.1016/j.carpath.2010.02.002

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Article

Elevated oxidative stress is associated with ventricular fibrillation episodes in patients with Brugada-type electrocardiogram without SCN5A mutation.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology - 1 Jan 2000

Tanaka Masamichi, Nakamura Kazufumi, Kusano Kengo Fukushima, Morita Hiroshi, Ohta-Ogo Keiko, Miura Daiji, Miura Aya, Nakagawa Koji, Tada Takeshi, Murakami Masato, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Kohno Kunihisa, Ouchida Mamoru, Shimizu Kenji, Yutani Chikao, Ohe Tohru, Ito Hiroshi

Abstract excerpt

BACKGROUND: Brugada syndrome is a disease known to cause ventricular fibrillation with a structurally normal heart and is linked to SCN5A gene mutation. However, the mechanism by which ventricular fibrillation develops in cases of Brugada-type electrocardiogram without SCN5A mutation has remained unclear. Recently, oxidative stress has been implicated in the pathophysiology of cardiac arrhythmia. We also...

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PMID: 20219395
DOI: 10.1016/j.carpath.2010.02.002

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