Article
Epigenetics in disease: leader or follower?
Epigenetics - 1 Jul 2011
Martin David I K, Cropley Jennifer E, Suter Catherine M
Abstract excerpt
Epigenetic silencing is a pervasive mode of gene regulation in multicellular eukaryotes: stable differentiation of somatic cell types requires the maintenance of subsets of genes in an active or silent state. The variety of molecules involved, and the requirement for active maintenance of epigenetic states, creates the potential for errors on a large scale. When epigenetic errors - or epimutations - activate or...
Topics
- Animals
- DNA Methylation
- Diploidy
- Epigenesis, Genetic
- Genetic Predisposition to Disease
- Humans
- Neoplasms
- Nuclear Proteins