Article
Independence of the carotene and sterol pathways of Phycomyces.
FEBS letters - 20 Jul 1992
Bejarano E R, Cerdá-Olmedo E
Abstract excerpt
Light, chemicals, and mutations that affect the carotene content of the fungus Phycomyces blakesleeanus had practically no effect on the ergosterol content. Lovastatin, a specific inhibitor of hydroxymethylglutaryl coenzyme A reductase, blocked growth at 1 microM; sodium DL-mevalonate (10 mM) fully reversed this inhibition. In the presence of [14C]mevalonate, a carS mutant accumulated 16 times more beta-carotene...
Topics
- Carotenoids
- Ergosterol
- Light
- Mevalonic Acid
- Mutation
- Phthalic Acids
- Phycomyces