Article
Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.
Molecular cell - 9 Dec 2005
Nicke Barbara, Bastien Julie, Khanna Sophia J, Warne Patricia H, Cowling Victoria, Cook Simon J, Peters Gordon, Delpuech Oona, Schulze Almut, Berns Katrien, Mullenders Jasper, Beijersbergen Roderick L, Bernards René, Ganesan Trivadi S, Downward Julian, Hancock David C
Abstract excerpt
The ability of activated Ras to induce growth arrest of human ovarian surface epithelial (HOSE) cells via induction of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) has been used to screen for Ras pathway signaling components using a library of RNA interference (RNAi) vectors targeting the kinome. Two known Ras-regulated kinases were identified, phosphoinositide 3-kinase p110alpha and ribosomal protein S6...
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