Article
The rapid generation of mutation data matrices from protein sequences.
Computer applications in the biosciences : CABIOS - 1 Jun 1992
Jones D T, Taylor W R, Thornton J M
Abstract excerpt
An efficient means for generating mutation data matrices from large numbers of protein sequences is presented here. By means of an approximate peptide-based sequence comparison algorithm, the set sequences are clustered at the 85% identity level. The closest relating pairs of sequences are aligned, and observed amino acid exchanges tallied in a matrix. The raw mutation frequency matrix is processed in a similar...
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