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Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP

11 Jun 2019

Abstract excerpt

Hepatitis B virus (HBV) infects the liver and is a key risk factor for hepatocellular carcinoma. Identification of host factors that support viral replication is important to understand mechanisms of viral replication and to develop new therapeutic strategies. We identified TARDBP as a host factor that regulates HBV. Silencing or knocking out the protein in HBV infected cells severely impaired the production of...

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PMID: 31186504
DOI: 10.1038/s41598-019-44934-5

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